"We were surprised to find that the same core principle of sequential and hierarchical DNA loop formation is used ... or to unpack them afterwards to read out the information they contain ...

The paper M. Ganji et al., “Real-time imaging of DNA loop extrusion by condensin,” Science, doi:10.1126/science.aar7831, 2018. How does a human cell neatly pack ...

"We were surprised to find that the same core principle of sequential and hierarchical DNA loop formation is used ... or to unpack them afterwards to read out the information they contain ...

The paper B.W. Bauer et al., “Cohesin mediates DNA loop extrusion by a ‘swing and clamp’ mechanism,” Cell, 184:5448–64, 2021. Approximately 2 meters of DNA is crammed into each of the human body’s ...

The relatively large bacterial DNA can then be separated from the smaller DNA loop that makes up the vector. Fill the syringe with the altered vectors. Upon inoculation, billions of copies of the ...

A schematic showing how R-loops, a hybrid of RNA and DNA, can form during DNA transcription when the messenger RNA chain being assembled by the RNA polymerase binds to one of the DNA strands.

It turns out that this process results from the original double-stranded DNA unwinding at a single spot ... As the double helix unwinds, it creates a loop known as the replication bubble, with ...