Unlike a band that would unwind if released, DNA gyrase stabilises DNA's twisted form, making it functional for bacteria. The enzyme wraps DNA in a 'figure-of-eight' loop, then precisely breaks ...

The FDA has approved the drug for use in women and girls over the age of 12 who suffer from uncomplicated urinary tract ...

Quinolones are widely used antibiotics that work by targeting the enzyme DNA gyrase which is essential to bacterial survival. Understanding the resistance mechanisms evolved by pathogens against ...

Moxifloxacin inhibits topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination. ≥18yrs: 400mg once daily.

Acurx Pharmaceuticals Inc (ACXP) progresses with phase 3 trials for Ibezapolstat while navigating financial hurdles and seeking strategic partnerships.

Levofloxacin inhibits bacterial topoisomerase IV and DNA gyrase (both of which are type II topoisomerases), enzymes required for DNA replication, transcription, repair and recombination.