To fit such a long molecule within the tiny space of the nucleus, DNA bends and loops in several ways. The largest of these loops results from the helical coiling of chromatin (the thick line in ...

"Stretching DNA refers to the process of stretching a single DNA molecule, which is originally coiled in a random coil, into ...

spiraled like a spring coil. In 1950, biochemist Erwin Chargaff found that the arrangement of nitrogen bases in DNA varied widely, but the amount of certain bases always occurred in a one-to-one ...

DNA is negatively charged ... by repeatedly folding chromatin fibers into a hierarchy of multiple loops and coils (Figure 1). Exactly how this is accomplished is unclear, but the phosphorylation ...

To achieve this, nature employs ingenious strategies, like twisting the DNA into coils of coils, so-called 'supercoils' (see ...