The researchers discovered that turning off the CUL5 gene improves CAR-T cell growth and longevity, even after repeated exposure to cancer cells.

The finding that reduced CUL5 gene activity increases CAR-T cell anticancer effects could improve treatment for patients with aggressive cancers such as leukemia, lymphoma, and multiple myeloma.

CUL5 also helps to pull the 'dividing-signal' proteins away from the protective shelter of HSP90, and labels them with a tag that sends them straight to the cellular dustbin -- effectively ...

CUL5 also helps to pull the 'dividing-signal' proteins away from the protective shelter of HSP90, and labels them with a tag that sends them straight to the cellular dustbin – effectively ...

Through a series of laboratory experiments, Dr. Yu's team further found that disruption of the Cul5-SCF function makes HIV less infectious and less able of suppress APOBEC3G and its protective ...

The finding that reduced CUL5 gene activity increases CAR-T cell anticancer effects could improve treatment for patients with aggressive cancers such as leukemia, lymphoma, and multiple myeloma.

A new study reveals that modifying the CUL5 gene enhances CAR-T cell therapy for leukemia and lymphoma. This improves cell longevity and tumor-fighting power, reducing cancer relapse.

The authors used an alternative technique to look at focal adhesions in cells that are not migrating. These images show two different components of the cell’s internal infrastructure in green and ...