Cre-loxP organisms are generally produced by separately creating Cre-lineage and loxP-lineage individuals that contain the ...

The resulting experimental mouse is hemizygous for Cre and homozygous for loxP (D). This is the necessary genotype required to conditionally knock out the target gene in the specific tissue. Laura is ...

They used the Cre-loxP system for these experiments, wherein GFP expression in the host cells was prevented by a STOP codon, flanked by the loxP sequence. On adding Cre recombinase, the enzyme ...

All our multiexpression systems (currently MultiBac, MultiMam and MultiColi) rely on in vitro Cre-loxP recombination of Acceptor and Donor plasmids to assemble multiprotein expression vectors. A ...

With the introduction of sequence-specific recombination systems such as FLP/FRT or Cre/LoxP, not only can one dramatically increase the efficiency of generating mosaic animals, but also control ...

The Yong Xu lab is interested in novel neural circuits, neurotransmitters and intra-neuronal signals that are critical for coordinated control of metabolism and behavior. We generate unique mouse ...

The Wang lab is interested in brain estrogenic actions in the regulation of energy and glucose balance under different physiological conditions, including: Sex differences in response to nutritional ...

Researchers at the University of Tsukuba have developed a vector that integrates the Cre enzyme gene with the specific DNA sequence loxP, which is its target. This vector allows the creation of ...

Mice and newts were applied to the one-step Cre-loxP organism creation technology by TAx9. In this study, the researchers succeeded in synthesizing a Cre-loxP integrated vector by placing a short ...