"Very lame and imperfect theories are sufficient to suggest useful experiments which serve to correct those theories and give birth to others more perfect. These, then occasion farther experiments ...

The cyclooxygenase-2 inhibitors are non-steroidal anti-inflammatory drugs used as an analgesic for many disorders. The COX-2 enzyme is predominantly located in the central nervous system and thus ...

That's because most NSAIDs, like ibuprofen, are COX-1 inhibitors, which block prostaglandins that produce inflammation. However, prostaglandins also protect your stomach lining (per the National ...

Other NSAIDs do not have this effect. Cox-2 inhibitors are a newer form of prescription NSAID. As you might guess, they only affect Cox-2 enzymes and not Cox-1. Two of them -- Bextra and Vioxx ...

This culminated in the introduction of a new class of anti-inflammatories — the COX2 selective inhibitors — with improved tolerance. There may be other forms of COX that could account for some ...

A drug developer's dream, rationally designed to quell inflammation, COX-2 inhibitors are also prime candidates for preventing cancer or its recurrence. Gary J. Kelloff, chief of the chemoprevention ...

Metformin and SGLT2 inhibitors are associated with similar rates of incident gout among patients with type 2 diabetes.

The secret to ashwagandha's pain-relieving properties is that it's a cyclooxygenase (COX) inhibitor. These are medications that manage and treat chronic pain. Some studies have found COX ...

selective COX-2 inhibitor, and 5-HT1B/1D agonist indicated for the acute treatment of migraine with or without aura. It also develops AXS-05 (dextromethorphan-bupropion), an investigational N ...

Additionally, COX-2 inhibition upregulated Nrf2, which helped alleviate erastin+DMSO-induced ferroptosis (p < 0.01). Read the full story here.

All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive ...