Carvedilol and metoprolol are both beta-blocker medications, which are a class of drugs used to treat various cardiovascular conditions like heart failure and hypertension (high blood pressure ...

However, it has been found that additional α-adrenergic blockade with carvedilol may increase the number of patients with hemodynamic responses resulting in a reduction in hepatic venous pressure ...

Maximum plasma concentrations of carvedilol occur 1-2 hours after oral administration. [9] Absolute bioavailability of carvedilol is approximately 23% due to extensive first-pass metabolism.