The role of the adapter protein PICALM (phosphatidylinositol-binding clathrin assembly protein) in the development of Alzheimer's disease is well documented. Researchers from the German Institute ...

Some steps of membrane transport require the formation of vesicles coated with COPI, COPII or clathrin. The coats probably generate the forces necessary to bend a relatively flat membrane into a ...

Clathrin-mediated endocytosis is a major endocytic route used by transferrin, growth-factor receptors and pathogenic viruses during infectious entry. Although clathrin-dependent uptake is the best ...

In our lab, we focus on clathrin-mediated endocytosis, the predominant route for membrane internalisation in most cells. In addition to its role in endocytosis, the clathrin machinery also forms ...

and/or through disrupted synaptic vesicle transport via clathrin-mediated endo- and exocytosis. This suggests that targeting CDC42 or its upstream regulator, ITSN1, might offer a therapeutic ...