The root-mean-square (r.m.s.) deviation between the two structures, which belong to the same subfamily of GPCRs (Class A), is 2.3 Å, and for the transmembrane helices only it is 1.6 Å.

“In the UK, we’re still focused on GPCRs, still firmly with our expertise in structure-based drug design, and still working with world-leading pharma companies to target new first-in-class or ...