The findings have been published in Nature. The team found that some pancreatic cancer cells gain a major survival edge by carrying copies of critical cancer genes—such as MYC—on circular pieces of ...

Pancreatic cancer’s deadly resilience may be tied to extrachromosomal DNA, which allows tumor cells to rapidly adapt to stress and evade treatment. These circular DNA fragments carry extra copies of ...

Circular DNA, thought to be an accidental byproduct, is borrowing the cell’s DNA repair mechanisms to copy itself DURHAM, N.C. -- Like its viral cousins, a somewhat parasitic DNA sequence called a ...

Ring-shaped extrachromosomal DNA is implicated in many cancers. Rachel Brazil talks to the scientists trying to uncover their ...

Scientists have provided the most detailed account yet of the earliest stages of DNA replication, an essential process for ...

Scientists suggest understanding ecDNA’s role in pancreatic cancer could potentially guide future strategies for making tumors more vulnerable to treatment.

The virus evades immune responses and antiviral therapies due to the persistence of covalently closed circular DNA (cccDNA), which serves as a viral reservoir. A recent review highlights how ...

Did you know that you have a second genome? Small cellular organelles called mitochondria contain their own circular DNA. What happens to your cells when this DNA mutates? Similar to the nuclear ...

During circular DNA replication, the excised primer is readily replaced by nucleotides, leaving no gap in the newly synthesized DNA. In contrast, in linear DNA replication, there is always a small ...

He wanted the DNA to contain the genetic information encoding most of the functions of SV40, all of the functions of the E. coli galactose (gal) operon, and the minimal parts of bacteriophage lambda ...