The cGAS-STING signaling pathway, a key element of the innate immune response, has risen as a promising avenue to amplify this therapeutic approach. Unraveling the pathway's role in immune system ...

The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...

Development of a new nano-immune agonist to improve immunotherapy for melanoma, a challenging skin cancer, by changing the ...

An artist's impression of cGAS-STING pathway response model for micronucleus. Before, cGAS's accumulation in micronuclei was considered to be an indicator of cGAS activation. Now, it was found ...

Researchers have developed an innovative nano-immune agonist that significantly improves immunotherapy outcomes for ...

knockdown of cGAS inhibited IRF3 and IFN-β induction, while overexpression ramped up IRF3 and IFN-β production through STING. The level of IFN-β induction by cGAS was similar to that of MAVS when ...