Scientists have uncovered a surprising trick used by the herpes simplex virus to wake up inside the body. Researchers at the ...

The cGAS-STING signaling pathway, a key element of the innate immune response, has risen as a promising avenue to amplify this therapeutic approach. Unraveling the pathway's role in immune system ...

Researchers have developed an innovative nano-immune agonist that significantly improves immunotherapy outcomes for ...

The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...

This previously unknown mechanism for spotting foreign genetic material in the cytoplasm launches antiviral defenses even when the well-known immune mediator STING is absent. A series of rodent ...

knockdown of cGAS inhibited IRF3 and IFN-β induction, while overexpression ramped up IRF3 and IFN-β production through STING. The level of IFN-β induction by cGAS was similar to that of MAVS when ...

An artist's impression of cGAS-STING pathway response model for micronucleus. Before, cGAS's accumulation in micronuclei was considered to be an indicator of cGAS activation. Now, it was found ...