However, Chen wanted to figure out the enzyme that made cGAMP. Through another series of biochemical fractionation and quantitative mass spectrometry, Chen narrowed his search to identify the enzyme ...

The new assay measures the enzymatic activity of cyclic GMP-AMP synthase (cGAS) by directly detecting the product cGAMP, in a simple mix-and-read format. Based on the proven Transcreener platform, ...

Our cells harbor a DNA detector termed cGAS to inform the immune system of ... immune cells by secondary messengers, ...