Netherlands biotech Azafaros is poised to start phase 3 trials of its lead drug for a trio of rare lysosomal storage ...

Researchers shed light on the "dark matter" of the gut, revealing a species of fungus that could potentially help counter ...

Utilizing a filamentous fungus in the gut microbiome may provide a new strategy for treating metabolic dysfunction-associated steatohepatitis (MASH). Researchers have developed an innovative method ...

Researchers at Peking University have discovered that a filamentous gut fungus, Fusarium foetens, can reverse metabolic ...

Their findings, published in Nature Metabolism, could eventually lead to drugs that reduce cellular ceramide levels, much like statins reduce cholesterol levels. "Rising ceramides in the cell are ...

"Nogo suppresses biosynthesis of ceramides, so if we can identify a drug that can block Nogo-B, we could restore ceramide levels to a healthy balance and this would fight not only obesity and ...

"Nogo suppresses biosynthesis of ceramides, so if we can identify a drug that can block Nogo-B, we could restore ceramide levels to a healthy balance and this would fight not only obesity and ...

One of the most promising commercially available solutions is a family of lipids called ceramides, which are composed of a sphingoid base and a fatty acid. Though ceramides have been used in ...

Trajkovic et al. now report that exosome biogenesis requires the sphingolipid ceramide, whereas the ESCRT (endosomal sorting complex required for transport) machinery is only needed for ILVs that ...

The researchers then investigated how the metabolisms of treated mice changed. They found that the effect was caused by slowed synthesis of fatty molecules called ceramides. Ceramides are important ...