They are non-integrating vectors so expression in dividing cells is progressively lost. First generation vectors may be suitable for applications where transient, high level activity is sufficient, ...

They can make gene delivery easy and efficient in a number of models of disease. The Vector Development Laboratory is located within the Cell and Gene Therapy Center on the 10th floor of the Alkek ...

The main problem is that most vector production technologies were developed for the lab, rather than to support industrial supply, ...

Plasmids naturally exist in bacterial cells, and they also occur in some ... Researchers can insert DNA fragments or genes into a plasmid vector, creating a so-called recombinant plasmid.

Additionally, improving CAR-T biological efficiency could reduce dosing needs, further cutting costs and expanding access. Today’s platforms and scientific advancements allow such optimizations, but ...

Genome editing via the all-in-one AAV vector showed considerable efficiency and specificity. It showed on-target T to C conversion in human cells, expressing the GJB2 R75W mutation, repaired the ...

First, the researchers developed an AAV (AAV-Sia6e) that can deliver genome editing tools to a wide range of inner ear cells that form gap junctions. AAV is a useful vector for delivering genes ...