Figure 2: Three-dimensional protein structures of CDK5–p25, GSK3β and ERK2. In all three kinases, the ATP-binding pocket is buried deep within the two lobes, the interface of which constitutes ...

Figure 1: Cyclin-dependent kinase 5 (Cdk5) downregulates peroxiredoxin-2 (Prx2) activity, leading to an accumulation of reactive oxygen species in the MPTP model of Parkinson's disease.