Figure 1: Cyclin-dependent kinase 5 (Cdk5) downregulates peroxiredoxin-2 (Prx2) activity, leading to an accumulation of reactive oxygen species in the MPTP model of Parkinson's disease.
Three kinases have been strongly linked to the aberrant phosphorylation of tau, cyclin-dependent kinase 5 (CDK5), glycogen synthase kinase 3β (GSK3β) and extracellular signal-regulated kinase 2 ...
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