CKI and Cdh1 make G1–S and M–G1 irreversible ... mitosis by CycB degradation caused by transient activation of APC–Cdc20, but they do not enter a stable G1 state. As soon as Cdc20 turns ...

(C, D) The prognostic significance of CDC20 in glioma via TCGA and CGGA-693 databases. (E) Immunohistochemical staining was performed to evaluate CDC20 expression in glioma tissue samples.

∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, and ∗∗∗∗P < 0.0001. (C) CDC20 and CCNB1 expression levels were detected by Western blot in the CDC20 rescue assay. (D) The proliferation ...