The researchers created an antibody that could both activate CD40 and carry cancer-specific peptides to immune cells. The study involved multiple steps: screening for potential antibodies ...

Alligator Bioscience has reported updated results with its CD40 agonist mitazalimab as a first-line treatment for advanced pancreatic cancer, a disease with few treatment options. The Swedish ...

The team also identified the CD40 protein as a potential target for triggering immune responses against ovarian cancer. Building on this discovery, Dr. Zsiros is leading a new Phase II trial ...

systemically administered immunotherapy designed to drive intratumoral expression of a CD40 agonist monoclonal antibody in both primary and metastatic tumor sites Proof-of-concept FORTRESS trial ...