Disrupting CD154–CD40 interaction using monoclonal antibody ... IL-10 and IFN-γ by a sandwich ELISA as described 19. Flow cytometric analysis of intracellular IFN-γ and IL-4 synthesis.

That is notable, given that some earlier members of the CD40 class had serious safety issues that led to them being abandoned, particularly Biogen’s ruplizumab and Idec Pharma’s toralizumab ...