The image shows a liver cell infected with 10200 strain of Crimean-Congo hemorrhagic fever virus (CCHFV). The red colored structures are the CCHF virions. Dr. Aura Garrison, Dr. Joseph Golden and ...

The image shows a liver cell infected with 10200 strain of Crimean-Congo hemorrhagic fever virus (CCHFV). The red colored structures are the CCHF virions. Use of image is permitted with permission ...

More information: Felix Pahmeier et al, Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread, Science Translational Medicine (2025). DOI: 10.1126 ...

CCHFV is endemic to Africa, the Balkans, the Middle East and Asia, and considered a priority pathogen by the World Health Organization. The virus is primarily transmitted to people from ticks and ...

[66] Crimean–Congo hemorrhagic fever virus (CCHFV) internalization is clathrin and pH dependent. The CCHFV replication cycle is dependent on actin and microtubule structures. The G N protein of ...

[67] However, the specific function of the CCHFV OTU protease remains to be elucidated. A fully functional reverse genetics system that could generate infectious viruses with the possibility to ...