(See 32 for a detailed discussion of properties of caspase inhibitors.) Approximately 1 h after CLP, mice received metronidazole (50 mg/kg) and ceftriaxone (6.25 mg/kg) by intraperitoneal (i.p ...

caspase-6, nuclear lamin, DNA-dependent protein kinase, and DNA fragmentation factor 45 (DFF45 or ICAD) 7. In particular, degradation of DFF45 releases its inhibition of DFF40 (or CAD), which ...

For example, researchers will measure cell death to determine a drug’s anticancer effectiveness. Scientists commonly use caspase assays to evaluate apoptosis, evaluating caspase activation—a hallmark ...