Active-site mutants of murine caspase 2 and an autocatalytic chimera of murine caspase 2 prodomain and human caspase 3 induced apoptosis that did not interfere with immunogen expression.

At 10 mg/kg, the degree of apoptosis was the same in septic mice treated with the caspase inhibitors and sham-operated mice. Figure 2: Effect of caspase inhibitors on lymphocyte apoptosis after ...

For example, researchers will measure cell death to determine a drug’s anticancer effectiveness. Scientists commonly use caspase assays to evaluate apoptosis, evaluating caspase activation—a hallmark ...

This focus has evolved to include the investigation of non-apoptotic functions of proteins that have long been considered to have roles in apoptosis, the caspase family of proteases. Our research ...