In addition to finding the inflammasomes associated with more severe disease, the researchers also found that caspase-1 and ...

Recently, it has been demonstrated that activated caspase-1 induces pyroptosis, inflammatory and necrosis-like programmed cell death, although it was previously thought to induce apoptosis.

Microorganism- and host-derived 'danger' signals stimulate formation of a multiprotein complex, termed the inflammasome, which leads to processing and activation of caspase 1. Active caspase 1 ...

Second, this study sheds light on the nature of the fundamental sepsis-induced defect that is treated by caspase inhibitors. RAG-1 −/− mice treated with caspase inhibitors did not have ...

In apoptosis, caspases act as executioners, but when summoned by necrosis across relatively long distances, another type of caspase appears to promote healing in certain cells instead.