Mutations in ATP8b1 are found in certain individuals susceptible to pneumonia. Ray et al. now report that bacterial pneumonia is associated with elevated levels of the phospholipid cardiolipin in ...

An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter. Proceedings of the National Academy of Sciences , 2020; 202000640 DOI: 10.1073/pnas ...

During apoptosis, proapoptotic BAX and BAK trigger mitochondrial outer membrane (MOM) permeabilization by a mechanism that is not yet fully understood. BH3-only proteins such as tBID, together ...

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A LINK BETWEEN CARDIOLIPIN, ENERGY AND CALCIUM. When cells need a burst of energy, they use calcium as a signal to urge mitochondria to ramp up energy production.

This paper reports on a correlation between diminished cardiolipin content and the severity of steatohepatitis in human subjects. This is supported further by experimental evidence from mice in which ...

Cardiolipin belongs to a class of molecules called lipids. Within muscle cells, cardiolipin is found in mitochondria, which are known as the "powerhouse" of the cell because they produce ...