Additional studies showed a role for the Cgs2 phosphodiesterase that hydrolyzes cAMP to AMP. In addition, we identified control elements upstream from the fbp1 promoter that are bound by ...

Phosphodiesterase-4 (PDE4), a member of the ... Blocking PDE4 activity with PDE4 inhibitors increases intracellular cAMP levels and effectively relieves the skin inflammatory phenotype of psoriasis.