However, such CYP3A4 inhibitors often affect the similar but distinct CYP3A5 due to the two proteins' shared features, such as large and promiscuous binding sites, in addition to other unintended ...

However, such CYP3A4 inhibitors often affect the similar but distinct CYP3A5 due to the two proteins’ shared features, such as large and promiscuous binding sites, in addition to other unintended CYPs ...

Large interethnic differences in allele frequencies exist for the functional CYP3A5*1 allele. CYP3A5 is a metabolizing enzyme expressed in the intestine, liver and kidney. CYP3A5 enzymatic ...

Enzymes catalyze nearly all of the chemical reactions that occur in biological systems. Enzymes are generally proteins but also include catalytic DNA and catalytic RNA. As effective biological ...