The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

They also found that targeting a pathway, called CXCR4, that is turned on in these cells can inhibit granulomas from forming. These findings suggest that clinicians may be able to diagnose ...

The study, "Cxcr4 Regulates a Pool of Adipocyte Progenitors and Contributes to Adiposity in a Sex-Dependent Manner," was published on August 5th, 2024 in Nature Communications. The researchers ...

Now, Bernhagen and colleagues, writing in Nature Medicine, have identified MIF as a ligand for the CXC-chemokine receptors CXCR2 and CXCR4, and suggest that targeting MIF could be used as an ...

Exicure, Inc. (Nasdaq: XCUR) today shared updates on its lead asset, GPC-100 (burixafor), a small molecule CXCR4 inhibitor. Exicure, Inc. ("Exicure") is planning for a clinical trial in Acute Myeloid ...

Interestingly, dasatinib treatment increased cell-surface expression of CXCR4, which is important for survival of B-lineage cells, but this did not promote survival. Combined treatment of cells ...