Interestingly, CTLA-4 knockout mice and mice that lack expression of CTLA-4 just in T REG develop fatal, early-onset lymphoproliferative disease. 1,4 In addition, expression and signaling of CTLA ...

PD-1, VEGFA, and CTLA-4 are clinically validated targets for immunotherapies, which can exert complementary, multi-dimensional anti-tumor effects through synergistic mechanisms. Blockade of PD-1 and ...

An important inhibitory molecule expressed by dendritic cells is Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Our lab has shown that DC CTLA-4 is expressed and secreted in extracellular ...