Our current DC CTLA-4 research focuses on identifying the gene regulation, and EV function of DC CTLA-4. Additionally, we will define the function of CTLA-4 by using DC conditional CTLA-4 mouse ...

Interestingly, CTLA-4 knockout mice and mice that lack expression of CTLA-4 just in T REG develop fatal, early-onset lymphoproliferative disease. 1,4 In addition, expression and signaling of CTLA ...

Anti-PD1/LAG3 reprogrammed CD8+ TILs with type 1 interferon and exhaustion-gene programs into effector and resident memory (T ...

Cancer Gene Therapy, vol. 26, no. 9 ... “Regulation and In Vivo Function of Dendritic Cell CTLA-4.” The Journal of Immunology, vol. 200, no. 1, 1 May 2018, p. 109.11. Liang, Dan, et al. “AIMp1 ...

Adagene Inc. announced a poster presentation for the ASCO 2025 conference in Chicago, highlighting the safety and efficacy of its product, ADG126, an anti-CTLA-4 masking antibody, in combination ...

Anti-PD-1 and anti-CTLA-4 are common drugs in treating cancers like melanoma ... such as targets for PD-1 and lymphocyte activation gene-3. “There is a lot of room to expand Cyclone to precisely ...

The most common immune checkpoints include the following. Due to the inhibitory effects of CTLA-4, PD-1, and PD-1 ligands on the immune response, researchers early on proposed that blocking these ...