This observation has led to the discovery and clinical development of therapy targeting the CSF1 receptor (CSF1R). Using x-ray co-crystallography to guide our drug-discovery research, we generated ...

Olmos-Alonso et al. have targeted a key factor in the proliferation of microglia surrounding amyloid plaques, colony-stimulating factor 1 receptor (CSF1R). Elevated expression of CSF1R is positively ...

A rare cause of hereditary cognitive decline known as CSF1R-Related Disorder (CSF1R-RD) gets its name from mutations in the ...

Research shows male microglia are more sensitive to disrupted CSF1R signaling, uncovering potential links to sex-based disparities in neurological disorders. Study: The microglial response to ...

Colony-stimulating factor 1 receptor (CSF1R)–dependent monocytes and macrophages are key mediators of chronic graft-versus-host disease (GVHD), a major long-term complication of allogeneic ...

In the brain, CSF1R is found only on microglia and infiltrating macrophages. In animal models, the ligand, CPPC, had bound poorly in healthy brain, but this doubled under inflammatory conditions.

Recently developed small-molecule drugs targeting colony-stimulating factor-1 receptor (CSF1R) -- a receptor kinase critical for survival and proliferation of CNS microglia, peripheral tissue ...

Scientists at the drugmaker Sanofi have identified a small molecule that can cross the blood-brain barrier and inhibit colony stimulating factor-1 receptor (CSF1R), a kinase that’s been linked ...

Sergio A. Giralt, MD, discusses how the pathophysiology of chronic graft-vs-host disease involves complex immune dysregulation, with CSF1R playing a crucial role in driving the differentiation of ...

Suppressing tumor-associated macrophages with a combination of a CSF1R inhibitor and the chemotherapy cisplatin could improve tumor response to anti-angiogenic immunotherapy in mice, the team ...