Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into ...

Expanding CRISPR's Potential Since its discovery, CRISPR (“Clustered Regularly Interspaced Short Palindromic Repeats”), which ...

Cas12a tool to enable simultaneous genetic modifications, allowing the study of complex genetic interactions in immune system ...

CRISPR-Cas12a is a programmable endonuclease used for genetic engineering. Here, the authors use real-time single-molecule measurements to show that Cas12a unwinds the target DNA site in dynamic ...

Despite its successes, the CRISPR-Cas9 system has several limitations, including off-target cutting. Over the years, scientists have explored alternatives to Cas9, such as Cas12a for more precise ...

Genetic engineering has revolutionized biomedical research, but optimizing these gene-editing tools remains a challenge. Scientists have now developed a novel approach using an enhanced version of ...

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into the roles that specific genes play in many diseases. But to date this ...

The new tool, which is called CRISPR-Cas12a, can help researchers simultaneously assess the impact of multiple genetic changes involved in variety of immune system responses, the researchers say.