To generate a tissue specific knockout mouse, researchers breed a mouse bearing a Cre transgene under a tissue- or cell-type specific or inducible promoter (A) with a homozygous floxed mouse (B). The ...

A current search for Cre recombinase transgenic mice in Medline yields over 900 publications, more than half of which were published in 2003 or later. In view of this popularity, it appears ...