The immunomodulatory character of bacterial CpG DNA is well known. A report in a recent issue of Nature pinpoints a Toll-like receptor as the cellular accomplice in this innate immune reaction.

By coupling a Toll-like receptor (TLR) agonist to small interfering ... In several mouse models of cancer, peritumoural injection of the CpG–siRNA construct resulted in internalization of ...

EMCV: Encephalomyocarditis virus; HCMV: Human CMV: MCMV: Mouse CMV; MMTV: Mouse mammary tumor virus; pDC: Plasmacytoid dendritic cell; PTV: Punta Toro virus; SARS-CoV ...