The first CF rat model, CFTR tm1sage (termed CFTR-/- or KO), was designed in collaboration with SAGE (now Horizon Discovery) and subsequently characterized at UAB and distributed to the CF community.

The CFTR Protein Distribution Core offers high-quality, full-length recombinant cystic fibrosis transmembrane conductance regulator (CFTR) proteins expressed in and purified from mammalian cells. Wild ...

The group with CFTR modulator exposure was made up of 114 pregnancies, of which 77 received a highly effective modulator therapy (HEMT). Notably, 74.23% predicted was the mean FEV 1 before ...

Estimates for 89bio’s loss per share have narrowed from $2.51 to $1.98 for 2025 in the past 60 days. During the same time frame, estimates for 2026 loss per share have improved from $2.94 to $2. ...

Kaftrio is already approved for use in CF patients aged two years and older who have at least one F508del mutation in the CFTR gene. The drug is marketed by Vertex for similar indications in the ...