The researchers discovered that those with Barrett's esophagus who never developed cancer had a higher prevalence of abnormalities in a gene called CDKN2A. This was surprising because CDKN2A is ...

In the p53 pathway, signals such as DNA damage induce the ARF (also known as p14 in humans and p19 in mice) product of the CDKN2A locus. ARF increases p53 levels by sequestering MDM2, which ...