Ovarian cancer, a leading cause of death among gynecological malignancies, has a poor prognosis and low 5-year survival rate, necessitating new therapeutic strategies. CDK4/6 inhibitors show promise ...

Further investigation into the role of CDK4/CDK6 in ESCC was conducted through CRISPR-mediated gene knockout experiments. The depletion of CDK4/CDK6 in ESCC cells not only reduced their ...

Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

and CDK4" has been published in Genes & Cancer. The MYC gene is a regulatory and proto-oncogenic gene that is overexpressed in the majority of prostate cancers (PCa). Numerous studies have ...