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When CDK12/13 stalls, healthy prostate cells take a malignant turn
In a recent study published in Cell Reports Medicine, researchers investigated whether loss of the cyclin-dependent kinase 12 (CDK12) gene drives prostate cancer (PCa) development. Cyclin ...
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CDK12/cyclin K degradation inducers disclosed in Proxygen patent
Proxygen GmbH has divulged molecular glue degraders comprising a cullin-ring E3 ligase (CRL)-binding moiety acting as cyclin-dependent kinase 12 (CDK12)/cyclin K degradation inducers reported to be ...