A new study in mice shows how the small GTPase Cdc42 influences bone modeling and remodeling—it modulates both the formation and function of osteoclasts, and is involved in the downstream ...

In vitro, activation of cell division cycle 42 (Cdc42) maintained the morphological characteristics of quiescent HSCs. Cdc42 activation in HSC cell lines inhibited the expression of markers ...

The researchers propose that loss of ITSN1 function may contribute to Parkinson's Disease pathogenesis through inactive CDC42 and its downstream pathways, degeneration of dopaminergic neurons and ...

The study reveals that AMs utilize cell division control protein 42 (CDC42)-mediated actin polymerization pathways for their ...

Cdc42, and the downstream kinase Pak1. Additionally, we have shown that the difference in susceptibility between BCG-permissive and BCG-resistant bladder cancer cells is due to oncogenic activation of ...

The Rho GTPases — which include the Rho, Rac and Cdc42 proteins — are encoded ... strategically situated within signal-transduction pathways that regulate myriad cellular functions ...