In mice infected with lymphocytic choriomeningitis virus (LCMV), Ahmed found PD-1 upregulated in functionally-impaired CD8 T cells. The team then showed that preventing PD-1 activation by blocking its ...

Nigel McCracken, chief operating officer, Virax Biolabs, discusses results from new data on the role of T cell dysfunction in ...

Preclinical data further support the potential of dual-antigen and TGF-β-directed vaccines to reshape the tumor microenvironment and drive anti-tumor immunity NEW YORK, April 25, 2025 (GLOBE NEWSWIRE) ...

Incyte (Nasdaq:INCY) today announced that the Company will present new early-stage data from its oncology portfolio at the ...

A new research paper was published in Oncotarget's Volume 16 on January 20, 2025, titled "Anti-correlation of KLRG1 and PD-1 expression in human tumor CD8 T cells." The study authored by Dr. Steven A.

gondii are unstable. Although the host contributes to this instability via expression of down-regulatory proteins (PD-1) on the surface of the CD8 T cells (Figure 2), whether and how the parasite ...

Additionally, PLT012 reshapes the exhaustion profile of cytotoxic CD8+ T cells by expanding both ... with immune checkpoint inhibitors such as PD-1 or PD-L1 inhibitors. Other than oncology ...

CD8 + T cells that normally kill cancer cells ... of three markers involved with antigen presentation, MHCI, MHCII, and PD-L1, and their release of two markers of immunogenic cell death, ATP ...