In other experiments, it seems as if there are steric effects such that as long as the CD8 mAb is labeled with PE (240 kDa), the non-antigen specific effects are abrogated. When CD8-mediated binding ...

To address this unmet medical need, Heat Biologics is developing drug candidates that turn immunologically ‘cold’ tumors ‘hot’ with a fresh infiltrate of CD8 + killer T cells, enhancing ...