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Study highlights potential for targeting macrophages to improve rheumatoid arthritis outcomes
Researchers demonstrated for the first time, the presence of a dominant macrophage subtype (CD40-expressing CD206+CD163+) in the inflamed RA synovium, which importantly was associated with disease ...
Nature10y
Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice
In addition, we here administered the CD40-TRAF6 inhibitor after 12 weeks ... Ly6G (BD Biosciences) and CD206 (BioLegend, San Diego, CA, USA) antibodies were incubated with the indicated tissues.
Study offers potential for early diagnosis and therapeutic intervention for rheumatoid arthritis
Researchers demonstrated, for the first time, the presence of a dominant macrophage subtype (CD40-expressing CD206+CD163+) in ...