Among the CCR5 inhibitors developed so far ... Importantly, the interaction between CXCR4 and its ligand SDF-1 is involved in various disease conditions, such as cancer cell metastasis, leukemia ...

Recent evidence that X4 variants can sometimes evolve in R5 HIV-1-infected hu-PBL-SCID mice treated with derivatives of the chemokine CCR5 ligand RANTES may not be predictive for clinical ...