CCR4 is expressed by several immune cells such as T helper 2 (TH2) cells, regulatory T cells (Tregs), mast cells, and skin-homing lymphocyte Ag–positive T cells. Its inhibition results in a ...

CCR4 is expressed by several immune cells such as T helper 2 (TH2) cells, regulatory T cells (Tregs), mast cells, and skin-homing lymphocyte Ag–positive T cells. Inhibiting the protein results ...

attracts regulatory T cells, which express the CCL22 receptor CCR4. An antibody against CCL22 prevented trafficking of regulatory T cells to human ovarian tumours in the xenograft model.

The US regulator has cleared Lymphir (denileukin diftitox) for the treatment of relapsed or refractory cutaneous T-cell lymphoma (CTCL ... and Kyowa Kirin’s anti-CCR4 antibody Poteligeo ...