Cellular and in vitro biochemical experiments showed that MARTRE1 functions as an inhibitor of the CCR4-NOT complex. When MARTRE1 was expressed in cells, it slowed the rate of poly(A) tail ...

The nuclei in our cells are miniature warehouses safeguarding ... The investigators detailed the involvement of a grouping of proteins called the CCR4-NOT complex, which is responsible for ...

Shanghai Pharmaceuticals Holding Co. Ltd. has identified C-C chemokine receptor type 4 (CCR4) antagonists reported to be useful for the treatment of asthma, allergic rhinitis, atopic dermatitis, ...

attracts regulatory T cells, which express the CCL22 receptor CCR4. An antibody against CCL22 prevented trafficking of regulatory T cells to human ovarian tumours in the xenograft model.