Sometime around 1914, Little obtained a female mouse, code numbered 57, and a male, numbered 52, which he inbred through at least twenty generations (3-4 generations a year). He named the resulting ...

What’s more, the C57BL/6 mice that Ulfhake studied are deficient in melatonin, a hormone with key roles in seasonal rhythms. During a recent study, German researchers compared seasonal ...

More information: Rukmani Cahill et al, 37-Day microgravity exposure in 16-Week female C57BL/6J mice is associated with bone loss specific to weight-bearing skeletal sites, PLOS ONE (2025).

The researchers utilized three generations of mice—F0 (grandfathers), F1 (fathers), and F2 (grandsons). The F0 generation ...