This process is considered as a basis for long-lasting memory. In this study, we will elucidate roles of C1q family proteins in regulation of synapse formation and maintenance in adult brain.

Tanruprubart is a first-in-kind monoclonal antibody designed to block C1q, the initiating molecule of the classical complement cascade. In the Phase 3 pivotal trial of 241 patients, tanruprubart ...

This revealed an astrocyte-driven upregulation of the levels of C1q complement protein mRNA. Next the authors investigated the normal expression of C1q in the CNS. Immunostaining showed that C1q ...

2011;9(12):1565-1584. The effector face, at the opposite side of the CRP pentamer, recognizes the complement pathway component (C1q) and cell surface Fcγ receptors (FcγRs). [14] It carries a ...

3 Adiponectin monomers usually form a collagen triple helix with a C-terminal trimeric globular C1q head domain ... and expression of vascular adhesion molecule 1 (also known as CD106 ...

(Nasdaq: ANNX), a biopharmaceutical company advancing a late-stage clinical platform of novel therapies for people living with devastating classical complement-mediated neuroinflammatory diseases of ...