This apoptotic process is controlled by a group of proteins called the BCL-2 family, which decides whether ... the researchers of this study deleted the MCL-1 gene from mice skin cells and removed ...

BAD is a pro-apoptotic member of the Bcl-2 family that is tightly regulated by ... BAD is not ubiquitously expressed 10, and mice that have had their BAD gene deleted are viable (S.

The landmark discovery of the BCL-2 gene and its function marked the inhibition of apoptotic cell death as a crucial mechanism driving cancer development. This new review brings together some of ...

The MYC gene is a regulatory and proto-oncogenic gene ... and change in the mRNA levels of BCL-2/Bax, PTEN, and CDK4 as a consequence of MYC downregulation. Moreover, the researchers analyzed ...