BRD4, a member of the BET protein family, plays a critical role in cancer progression by regulating oncogenes, particularly MYC, which drives tumor growth but is difficult to target directly.

The study also highlights the complex relationship between BRDT and a related cancer-driving protein, BRD4. While the two share some overlapping functions, BRDT was found to perform certain ...

Acetylated histones at active enhancers and promoters recruit bromo and extra terminal repeats (BET) protein called BRD4. We recently demonstrated that de novo mutations in BRD4 cause a ...