BRD4, a member of the BET protein family, plays a critical role in cancer progression by regulating oncogenes, particularly MYC, which drives tumor growth but is difficult to target directly.

The candidate, dubbed DC-9476, targets the BRD4 protein, which regulates gene expression by binding to specific marks on histones. By selectively inhibiting the BD2 domain of BRD4, DC-9476 reduces ...

Acetylated histones at active enhancers and promoters recruit bromo and extra terminal repeats (BET) protein called BRD4. We recently demonstrated that de novo mutations in BRD4 cause a ...